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Circulation 128 , 17481757 (2013)

Their mechanisms include: Neurotransmitter release : They increase the release of dopamine and noradrenaline in the brain Reuptake inhibition : They block the reuptake of these neurotransmitters, prolonging their activity Cognitive enhancement : In ADHD, they improve attention, focus, and impulse control Appetite suppression : As a secondary effect, they typically reduce appetite through central mechanisms Cardiovascular stimulation : They increase heart rate and blood pressure through sympathetic nervous system activation Lisdexamfetamine is a prodrug that is converted to dexamfetamine in the body and provides a longer duration of action (typically up to 14 hours), while dexamfetamine is available in immediate-release tablets (lasting 3-5 hours)

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GLP-1 drugs are generally contraindicated Personal or family history of medullary thyroid cancer (MTC): GLP-1 drugs carry a boxed warning for thyroid C-cell tumors in rodent studies Multiple Endocrine Neoplasia syndrome type 2 (MEN 2): Increased MTC risk History of pancreatitis: GLP-1 drugs may increase pancreatitis risk Type 1 diabetes: Not studied