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However, GLP-1 agonists do not significantly alter serotonin pathways, making serotonin syndrome an extremely unlikely concern with this combination

[DOI] [PMC free article] [PubMed] [Google Scholar] 122.Blau J.E., Tella S.H., Taylor S.I., Rother K.I

doi: 10.1073/pnas.1711235114 14 CerroE

By coupling GLP1-R agonist and GIP agonist together (seen in Tirzepatide), reduced reward-seeking behavior induced by the former may be strengthened by the enhanced mTOR effect of the latter, reinforcing neural circuits involved in executive control and decision-making, potentially counteracting the dysregulated reward pathways seen in addiction (Figure 3) [46,51]