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(2023, New England Journal of Medicine) Obesity Trial Study Design : Randomized, double-blind, placebo-controlled Phase 2 trial in adults with obesity or overweight

Seek immediate medical attention if: You experience sudden, severe pain with numbness or weakness in any extremity

The authors noted that mechanisms potentially involved include modulation of dopamine release, suppression of neuroinflammation, and attenuation of stress-related neural circuits

The compounded formulations that include B12 or glycine do not appear to significantly change the dry mouth profile, though some users anecdotally report that glycine-B12 blends produce slightly fewer side effects overall

Maintain through stabilization