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10.1111/dom.12377 24

Conversely, inhibition of cAMP upon Gi-coupled receptor activation inhibits GLP-1 secretion [19

Adults with obesity (BMI 30) or overweight (BMI 27) with conditions like hypertension

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While there is limited evidence regarding tirzepatide use specifically in patients with significant thyroid disease (as these patients were typically excluded from pivotal trials), there is no established direct pharmacological interaction between tirzepatide and Graves disease pathophysiology