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Our analysis identified a calcium signaling bottleneck as the central explanation for the EVOKE biomarker-clinical disconnect why semaglutide reduced CSF tau and neuroinflammation markers by ~10% yet failed to slow cognitive decline on CDR-SB

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China is powering Indias semaglutide launch QYOBO supply chain analytics for semaglutide API sources across 12 MA holders launching in India shows: 8 companies (67%) show partial or full dependence on China: 3 companies (25%) are fully reliant on China for API manufacturing 5 companies (42%) source APIs from two countries - but all still include China Only 3 companies (25%) show no direct China exposure at the API manufacturing level: Abbott and Emcure via Novo Nordisk in-licensing from Denmark Zydus with API manufacturing in India But China dependency is still present among these companies - just further upstream