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Typically, GI side effects of GLP-1s, such as nausea and vomiting, are dose-dependent, mild-to-moderate in severity, and occur mostly during initiation of therapy and up-titration

However, significant challenges persist, including concerns related to immunogenicity, limited reproducibility, high manufacturing costs, and the lack of validated clinical biomarkers for therapeutic response

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Some GLP-1 analogs use recombinant fermentation processes

Metabolic improvements from GLP-1 therapy may benefit breast cancer survivors, as obesity and insulin resistance are associated with poorer cancer outcomes