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The baseline cancer risk in populations with obesity and type 2 diabetes is elevated compared to the general population, independent of medication use

Both trials included patients with obesity-related HFpEF, defined by specific criteria, including elevated left ventricular filling pressures and structural heart abnormalities

Those qualifying conditions include type 2 diabetes, hypertension, high cholesterol, obstructive sleep apnea, cardiovascular disease, polycystic ovary syndrome, and non-alcoholic fatty liver disease

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This shift from a state of high "incentive salience" (wanting) to one of relative indifference is a powerful mechanism for sustaining behavioural change, as it reduces the internal psychological conflict that derails most diet attempts