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Nevertheless, these findings have not been replicated in robust human clinical trials, and the relevance to Hashimoto's management remains speculative

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[DOI] [PubMed] [Google Scholar] 23.Pfeffer MA, Claggett B, Diaz R, et al

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While genetics do not predict exact medication response, pathway predispositions may help contextualize why you experience fatigue and inform dosing strategies or additional monitoring to mitigate it