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ligand binding makes the cleavage site accessible, leading to shedding of the Notch ectodomain as the first step of signal transduction [[3][3], [4][4]]

Furthermore, no food, beverage or other medication can be consumed for another half hour

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Across randomized trials, stopping GLP-1/dual incretin therapy is typically followed by clinically meaningful weight regain and loss of cardiometabolic gainsoften within monthshighlighting obesity as a chronic, relapsing condition.

As in adults, gastrointestinal adverse effects were commonly seen