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Limited preclinical and clinical data suggest that GLP-1 receptor agonists might modestly influence cortisol metabolism or HPA axis function in certain contexts, but findings have been inconsistent and not practice-changing

So, 47% more people lose more than 10% of body weight on lifestyle interventions with semaglutide compared to lifestyle interventions alone

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The glucagon receptor activation drives this effect by promoting hepatic fat oxidation, essentially telling the liver to burn its stored fat reserves

2.1 Anti-inflammatory signaling and antioxidant effect Low-grade vascular inflammation is a central driver of atherogenesis, promoting monocyte recruitment, cytokine secretion, and plaque progression ( 2.2 Improvement of endothelial function and reduction of adhesion molecules Endothelial activation is an early biochemical event in atherosclerosis, characterized by increased expression of adhesion molecules, including Intercellular Adhesion Molecule 1 (ICAM-1), vascular Cell Adhesion Molecule 1 (VCAM-1), Monocyte Chemoattractant Protein-1 (MCP-1), and L-selectin