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By using ligand-receptor capture analysis, we found that P9 interact with intercellular adhesion molecule 2 (ICAM-2) and finally interleukin-6 deficiency abrogates the effects of P9 in glucose homeostasis and downregulates ICAM-2 expression

Abstract Background/objectives: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used in treating type 2 diabetes and obesity, offering established metabolic and cardiovascular benefits

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That means protein on semaglutide is not just important