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Medications targeting similar or additional incretin pathways come closest to replicating tirzepatide effects

[162] In March 2023, a Novo Nordisk official said, based on a randomized, double-blind study (NCT03548935 [163] ) funded by the company, that people using semaglutide to lose weight regained two-thirds of their original weight loss one year (52 weeks) after discontinuing use of the drug

however, their effects on OA incidence remain incompletely understood

106 Additionally, Tanzeum is not suitable for treating type 1 diabetes or diabetic ketoacidosis, related to its pharmacological action and target disease

If you have insulin resistance, though, there may be a net-positive benefit to taking a GLP-1
