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The presence of abdominal obesity is associated with changes in vascular function independently of other cardiovascular risk factors

Side effects include nausea and gastrointestinal issues, and many patients report reduced cravings, but also a loss of appetite or inability to enjoy certain foods

Journal reference: Xie Y, Choi T, Al-Aly Z (2026)

They jump straight to the standard 2.5 mg weekly dose, experience a wave of nausea that lasts for days, and either white-knuckle through it or quit entirely