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doi: 10.1056/NEJMoa1612917 16 GreenJBHernandezAFDAgostinoRBGrangerCBJanmohamedSJonesNPet al

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However, the SURMOUNT-5 trial compared tirzepatide to semaglutide 2.4mg (a more potent GLP-1 agonist than liraglutide), and tirzepatide still showed superior weight loss: 20.2% vs 13.7% at 72 weeks

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In clinical trials, the most common observations were gastrointestinal effects: nausea (44.2% vs 17.4% placebo in STEP 1), diarrhea (30.0%), vomiting (24.8%), and constipation (24.2%)

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