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doi: 10.1056/NEJMoa1612917 16 GreenJBHernandezAFDAgostinoRBGrangerCBJanmohamedSJonesNPet al
If bothersome, talk to your doctor about alternative medications or ways to manage this side effect
However, the SURMOUNT-5 trial compared tirzepatide to semaglutide 2.4mg (a more potent GLP-1 agonist than liraglutide), and tirzepatide still showed superior weight loss: 20.2% vs 13.7% at 72 weeks

In clinical trials, the most common observations were gastrointestinal effects: nausea (44.2% vs 17.4% placebo in STEP 1), diarrhea (30.0%), vomiting (24.8%), and constipation (24.2%)

Each article looks at one capability through a practical lens: what it is, how it works, who it supports and why it matters
