semaglutide difference tirzepatide GLP-1 Vs Zepbound For Weight Loss Semaglutide vs Tirzepatide: 2026 Comparison

For those exploring broader peptide options alongside tirzepatide, see our guides on best peptides for weight loss , peptides for weight loss overview , and the comparison of GLP-1 effectiveness timelines

Constipation On the opposite end, constipation affected 24.2% of semaglutide 2.4 mg users versus 11.1% on placebo in the STEP trials

These vials will be made available only through LillyDirect, a telehealth platform the company launched in January that connects patients with providers who can prescribe obesity drugs

How Semaglutide works Slows how quickly food leaves the stomach, which helps you feel full for longer Decreases appetite and reduces cravings, making it easier to avoid mindless snacking Improves insulin sensitivity, which supports steadier energy and better metabolic control FDA approvals Semaglutide was first approved to treat type 2 diabetes

Can tirzepatide injections cause weight gain if dosed less frequently