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References Eng J et al

Oral tirzepatide Oral tirzepatide is in advanced development and early data suggests it may achieve weight loss results closer to injectable tirzepatide than oral semaglutide achieves relative to its injectable counterpart

For obesity treatment, only liraglutide 3.0 mg, semaglutide 2.4 mg, and tirzepatide 5, 10, and 15 mg are licenced in adults

doi: 10.1016/j.amjms.2017.05.002

How peripherally administered GLP-1 induces satiety mechanistically is unclear, but it is postulated that signals being generated by the binding of GLP-1 to its receptor on neurons in the GIT, hepatoportal bed and CNS mediate this effect