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The metabolic dysfunction that leads people to need GLP-1 medications may be partly downstream of the same NAD+ depletion those medications are compensating for

Enhanced bioavailability: black pepper extract increases the bioavailability of berberine and white mulberry by 30%**

DOI: 10.1038/s44360-026-00108-y The authors report no outside funding

GLP-1s may be a worthwhile investment, but their value depends on how they are implemented and supported

During this time, all GLP-1RAs were approved for T2DM, and the analysis was therefore limited to comparing GLP-1RAs with other anti-diabetic medications in this population