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Description
Some medical conditions may prevent safe use
Animal studies showed increased rates of pregnancy loss, reduced birth weight, and some developmental abnormalities when tirzepatide was administered during organogenesis (the critical period of organ formation in early pregnancy)
Retrospective database studies suggest that adherence and persistence rates with once-weekly injectable GLP-1 receptor agonists are better than those achieved with more frequently dosed treatments (5356)
Impact of BMI and comorbidities on efficacy of once-weekly semaglutide: Post hoc analyses of the STEP 1 randomized trial
they're most effective when paired with lifestyle changes
