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The effect on stroke is remarkable (and was significant in the trials of both semaglutide and dulaglutide), amounting to an 18% risk reduction, also because the other class of new antidiabetic agents with cardiovascular benefits, the SGLT2-inhibitors, show no a similar effect on stroke (but do have a significant effect on heart failure) [24]

By choosing whole foods and meals with complex carbohydrates, lean proteins, and healthy fats, people using semaglutide can help keep their blood sugar stable and maximize the medications benefits

Notably, a dedicated renal outcome trial showed that semaglutide reduced the risk of major kidney outcomes in patients with T2DM and established chronic kidney disease [36]

This leads to more consistent and reliable outcomes

Adverse events outcomes (n = 21,229) were reported including 1,039 deaths (4.9% of all reports), 1,613 life-threatening events (7.6%), and 7,426 hospitalizations (35%)