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After 48 weeks of treatment, participants receiving 8 mg and 12 mg doses experienced a mean body weight reduction of 22.8% and 24.2%, respectivelyan outcome comparable to bariatric surgery

Neuron 107(3):496-508.e496

Retatrutide SLU-PP-332 is a novel small molecule and a potent pan-agonist of the estrogen-related receptors (ERR, ERR, and ERR), which are key regulators of energy metabolism and mitochondrial function

In the Phase 3 TRIUMPH-4 trial, participants taking 12mg of retatrutide lost an average of 28.7% of their body weight over 68 weeks