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The review revisited SUSTAIN-6, where semaglutide-treated patients showed a hazard ratio of 1.76 for retinopathy complications compared with placebo. The discussion has since shifted toward whether rapid metabolic changerather than direct retinal toxicitymay explain the signal

These findings suggest that retatrutide may have a favourable impact on metabolic health, potentially offering additional benefits beyond weight loss

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This is the first published trial to study the impact of a GLP-1 RA in a population with significant CKD, and it supports the renal benefits that had previously been suggested in some of the GLP-1 RA cardiovascular outcome trials

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