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GCGR, glucagon receptor

These effects were achieved through direct vasoactive and anti-inflammatory effects of exendin, as well as modulation of the pulmonary artery smooth muscle cell phenotype

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The SUMMIT trial demonstrated that treatment with tirzepatide reduced the risk of a composite of cardiovascular-related deaths or worsening heart failure, compared with placebo, and improved the health of patients with heart failure with preserved ejection fraction and obesity [147]