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Understanding these helps explain why temperature management consistently ranks as the most impactful intervention for reducing injection pain

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Therefore, defective Notch pathway alters keratinocytes proliferation and differentiation program, compromises apocrine gland homoeostasis and switches the fate of outer root sheath hair follicle cells, converting it into keratin-enriched epidermal cysts, a typical phenotypic trait of HS [45, 51, 52]

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