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About the ATTAIN-2 Trial Design : Phase 3, 72-week, randomized, double-blind, placebo-controlled

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How GLP-1s cause weight loss There are three GLP-1 agonists approved in the last few years for the treatment of obesity: tirzepatide (Zepbound), semaglutide (Wegovy), and liraglutide (Saxenda)

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When semaglutide suppresses appetite and reduces caloric intake by 20 to 40%, the body enters a state of energy deficit

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Dual GLP-1/GIP mechanism for appetite and glucose regulation

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Observational studies indicate that older GLP-1RA users experience greater proportional lean mass loss than younger adults [14]

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