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At the time, the approval was seen as a major step forward for diabetes care
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GLP-1 medications may help by reducing inflammation and supporting weight loss, both of which can improve psoriasis severity
Changes in HbA1c throughout the study were also not associated with reduced MACE.24 Additionally, the multiple pleiotropic effects of SEMA on metabolic, hepatic and renal function may indirectly contribute to cardiovascular protection.25 The HFpEF programme shows significant symptomatic improvement of heart failure symptoms with preserved ejection fraction (HFpEF) in obese patients treated with SEMA 2.4 mg26 (Fig
