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Weight-loss drugs have tried to counteract this biological battle for decades

Bikou A, Dermiki-Gkana F, Penteris M, Constantinides TK, Kontogiorgis C

Many people starting weight-loss medications actively seek out stomach relief but end up falling into the "Fiber Trap." While choosing Miralax or Metamucil might seem like a simple choice, bulk-forming fiber supplements like Metamucil can actually worsen abdominal pain when your digestion is slowed down

Manufacturers often promote such products as highly effective, but the real-world benefits may be far less than advertised

In parallel, glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide and tirzepatide, have transformed the therapeutic landscape of T2D and obesity by producing profound weight reduction, improvements in glycemic control, and cardiovascular risk reduction [7,8]