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Reduced DPP4 Activity Improves Insulin Signaling in Primary Human Adipocytes

Cell cycle analysis in these mutants determined that fbf-2 is required to regulate meiotic entry, with a loss of fbf-2 resulting in a reduced rate of meiotic entry and decreased cell division rates leading to an increase in the progenitor zone (Wang et al., 2020)

Semaglutide has previously been hailed as a new and effective treatment for obesity, but how does it work and what are the considerations

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TRIUMPH-1 (NCT05929066), the Phase 3 registration trial for the obesity indication, reported topline results on May 21, 2026 : average weight loss of 28.3% at 80 weeks at the highest dose in 2,339 participants, versus 2.2% on placebo, and 30.3% at 104 weeks among participants with a BMI of 35 or above who continued in a pre-specified extension