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Rational design of alpha-helix-stabilized exendin-4 analogues

The results of clinical trials have not matched expectations based on the positive results from preclinical studies

The meta-analysis involved 3281 individuals in the GLP-1RA treatment group and 2510 patients in the control group

FFAR3 and FFAR2 are present on hormone-producing enteroendocrine cells (EECs): exposure to SCFAs stimulates EECs differentiation (71), and binding of SCFAs to FFAR3 and FFAR2 results in altered gene expression and secretion of gut hormones, such as peptide YY (PYY) and glucagon like peptide-1 (GLP-1) (72, 73)

Rising diabetes prevalence and expanding healthcare infrastructure are driving demand for GLP-1 drugs across pharmaceutical companies, healthcare providers, and digital health platforms throughout major Chinese healthcare centers