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DPP-4 inhibitors (such as sitagliptin or linagliptin) should not be used concurrently with GLP-1 receptor agonists due to overlapping mechanisms

They have accumulated hundreds of independent lab tests

Both deliver dramatic appetite reduction and proven 15-20% average body weight loss

The SURMOUNT-1 clinical trial, published in the New England Journal of Medicine, demonstrated average body weight reductions of up to 20.9 percent over 72 weeks among participants taking Tirzepatide

Consistent with this concept, GLP-1RAs have been shown to directly modulate immune responses by reducing the secretion of key pro-inflammatory cytokines such as IL-6 and TNF-, which are central drivers of inflammation in both PsO and PsA (70, 71)