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however, these treatments often have poor therapeutic efficacy, significant side effects, and unavoidable weight rebound

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The mechanisms behind the renoprotective effects of GLP-1 RAs involve anti-albuminuric, anti-inflammatory, natriuresis, anti-atherogenic, and anti-oxidant effects through protein kinase A signaling, induction of natriuresis by inhibiting sodium-hydrogen exchanger 3, and a reduction in hyperfiltration 27,30,31

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The semaglutide plateau phenomenon also deserves mention here

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