retatrutide weight loss clinical trials results produces up to 30.3% in Phase 3 trial Effects of once-weekly subcutaneous retatrutide
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Side note: an example of this playing out in reality is that the cash prices of insulin have been increasing over the last decade but the net price (amount pharma receives) has been decreasing

The natural variation in gastric emptying is thought to account for at least 30% of the variance in the initial post-meal glucose response (030 minutes post-meal) in health

Horm Metab Res 2004
The Mifflin-St Jeor equation doesnt capture this directly, so people with more muscle than average tend to need slightly more calories than the calculator estimates

Microdosing and Weight Loss: Is There Data