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At present there are two classes of drug that potentiate the incretin effect as a means of improving glycemic control in type 2 diabetes

doi: 10.1111/dom.14775 [DOI] [PMC free article] [PubMed] [Google Scholar] 201.Gastaldelli A, Cusi K, Fernndez Land L, et al

Long-term effects of intensive glucose lowering on cardiovascular outcomes

3,507 GLP-1RAs reduce liver fat accumulation by activating AMPK, which inhibits fatty acid synthesis enzymes and promotes fatty acid -oxidation, thus diminishing lipid droplet accumulation in hepatocytes

Notably, the manufacturer has filed with the FDA for a second indication to reduce MACE in adults with T2D and established cardiovascular disease