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Pharmacological Background Pharmacologic treatments have evolved from toxic early options like dinitrophenol and amphetamines to modern drugs including orlistat, naltrexone, bupropion, phentermine, topiramate, and GLP-1RAs [11]

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Weight loss may accelerate during this phase

Clinical Trial Evidence and Findings in Female Participants Phase 2 trial data (Jastreboff et al., NEJM, 2023) showed dose-dependent weight reduction and metabolic improvements, but sex-disaggregated results were not published, so female-specific efficacy cannot yet be confirmed