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Bile acids Bile acids are amphipathic molecules that mediate the absorption of dietary fats and lipid-soluble vitamins

GIP Agonism: Activates GIP receptors which synergize with GLP-1 to enhance insulin response and are thought to reduce the nausea commonly associated with GLP-1 drugs alone

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The lack of data regarding exposure specifically during the first trimester is unfortunate

There is still a negative deflection for 9/12mg arms suggesting we have not reached max reduction in A1c and keep in mind this is retatrutide alone, with no other medications allowed