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Though rare, its possible to have a negative reaction to a peptide

Hunt B, Mocarski M, Valentine WJ, Langer J

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 10, 513519
Identifying a semaglutide-induced rash involves recognizing specific characteristics of the rash and differentiating it from other skin conditions

Nausea initialization onto GLP-1 therapies can cause significant nausea
