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Within the dorsomedial hypothalamus, GLP1 receptors are expressed on GABAergic neurons independent of NPY neurons (Lee et al., 2018)

While a definitive causal link cannot be established, the temporal relationship, exclusion of common viral symptoms, and recovery after drug discontinuation raise the possibility of a drug-related adverse event

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Hyperglycemia may cause vagus nerve dysfunction due to demyelination [38]

The SURMOUNT-5 trial found approximately 20.2% average body-weight loss with branded tirzepatide versus 13.7% with branded semaglutide over 72 weeks in adults with obesity and without diabetes