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Upon endocytosis by the endothelial cells, albumin binds to the Fc receptor (FcRn) during endosomal acidification, which sorts the intracellular trafficking of the albumin away from degradative lysosomes and back to the plasma membrane where it can once again reenter the general circulation

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doi: 10.1016/j.cmet.2013.04.008 2 NauckMAMeierJJ

The most important takeaway is this: slower gastric emptying can lead to delayed, stronger, and sometimes inconsistent THC effects, especially with edibles

Where feasible, genetic/omic data (e.g., PRS, metabolomics/lipidomics) can help identify high-responder subgroups (186188)