glp 1 agonist addiction GLP-1 receptor agonists show promise in treating substance use disorders GLP-1 Receptor Agonists and Research

Faculty of Medicine, McGill University, Montreal, QC, Canada

The mechanism of action of GLP-1 agonists involves binding to GLP-1 receptors on pancreatic beta cells, which stimulates glucose-dependent insulin secretion

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Each of the three pathways contributes different effects: GI Side Effects (Primarily from GLP-1) The GLP-1 component is responsible for most gastrointestinal side effects because it slows gastric emptying and affects gut motility: Metabolic Effects (From Glucagon Component) The glucagon component may cause slight increases in: Heart rate: Average increase of 5-10 bpm due to increased metabolic rate (similar to tirzepatide) Body temperature: Some users report feeling warmer, especially after meals (thermogenesis) Energy levels: Variable

Two pharmacoepidemiological analyses using electronic health records have reported that use of GLP-1R agonists is associated with lower rates of opioid overdose