glp-1 explanation receptor agonists Mechanisms of GLP-1 Receptor Agonist-Induced

Description

Relation to Neuroprotection: Such synthetic substances bind to GLP-1 receptors in the cortex, hippocampus, amygdala, and basal ganglia, triggering the following signal transduction: Switching off inflammatory NF-B downstream pathways like cytokines (IL-1/IL-6) and tumor necrosis factor (TNF-)

That said, theres a lot of attention on GLP-1 agonists for weight loss and diabetes, which means theres going to be a lot of funding for research

In the hippocampus, PAS # reversed the down-regulation of brain-derived neurotrophic factor and inflammatory cytokines induced by CUMS, which might partially explain its antidepressant effect [69]

However, the abundance of the Amuc_1409 protein is 263 times lower than PAS [Table 2], so it is unclear whether the concentrations used in this study are representative of the physiological concentrations in the gut