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Description
T2DM is characterized by the presence of chronic fluctuating hyperglycemia, obesity-associated insulin resistance as well as the impaired secretion of insulin and dysfunction of the incretin system

Though his HbA1c level dropped after adding the SU, over 2 years it has crept up to 8.6% and his mean blood glucose is 186 mg/dL

Incretins are gut secreted hormones, G-protein-coupled receptor peptides, that include glucagon-like peptide 1 (GLP-1), gastric inhibitory polypeptide (GIP) and glucagon (GCG)

P.Michaud-HerbstA.TremblayK

For any compound to work transdermally, it must be small enough to penetrate through multiple skin layers and achieve therapeutic concentrations in the bloodstream
