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According to the National Institutes of Health (NIH- department of the HHS), there is concern for acute pancreatitis and long-term consequences on the thyroid gland with usage of the GLP-1 RA medication

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Blunted FAA in GHSR knock-out (KO) mice is associated with decreased neural activation in the hypothalamus [52], VTA, and ACB shell [53]

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How GLP-1s help manage type 2 diabetes GLP-1s were first approved by the FDA for this exact reason: to manage type 2 diabetes by lowering blood sugar levels to a more normal fasting range and by improving insulin sensitivity

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Reduced Glucagon Levels: Decreases glucagon secretion, preventing excess glucose production

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