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Regardless of cause, sustainability of outcomes remains unclear because adherence to treatment, as with many other drugs, may be an issue

This way, the medicine can support weight reduction and make blood glucose levels, glycemic control, and insulin sensitivity better

Side Effects Comparison Both medications share similar gastrointestinal side effects due to their impact on slowing gastric emptying and reducing appetite: Nausea Vomiting Diarrhea Constipation Sulfur burps (more common with semaglutide) However, some reports suggest that tirzepatide may be better tolerated at lower doses, possibly due to the GIP component mitigating some of the gastrointestinal effects

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Most of this weight loss occurs within the first 68 to 72 weeks of treatment, so patience and consistency are key