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Therefore, we prioritized univariable MR analysis, which demonstrated a robust association between GLP-1RAs and arrhythmias

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Nevertheless, the overall trend suggests a reduction in basal insulin dose by up to 17% and a decrease in prandial insulin dose by up to 30% in addition of GLP-1RA to insulin therapy, especially with long-acting forms [32]

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By Administration Route Most GLP-1 receptor agonists are administered by subcutaneous injection because they are peptide-based molecules that would be degraded by digestive enzymes if taken orally