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Future Directions and Challenges in Translating GLP-1RA-Based Therapies to Neuropathic Pain Treatment One of the key challenges in advancing GLP-1RA-based therapies for neuropathic pain is the unclear expression of GLP-1R in the spinal cord

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Serious but less common risks include pancreatitis, gallbladder problems, and kidney injury from dehydration

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Experimental and clinical studies suggest that GLP-1 signalling may influence cytokine production, immune cell activation, and tissue inflammation ( In contrast, DPP-4isanother widely used incretin-based therapyhave been consistently associated with dermatologic adverse effects, particularly autoimmune blistering diseases such as bullous pemphigoid ( Although rare cutaneous adverse reactions to GLP-1 RAsincluding hypersensitivity reactions, eosinophilic panniculitis, bullous pemphigoid, and morbilliform drug eruptionshave been reported ( Unlike prior studies that focused on single dermatologic outcomes or non-comparative designs, the present study emulates a target trial to provide comprehensive, comparative dermatologic safety data for GLP-1 receptor agonists versus DPP-4 inhibitors across a broad spectrum of autoimmune and inflammatory skin diseases