jardiance a glp 1 Eli Lilly, Boehringer hit FDA roadblock in quest to repurpose for Type diabetes Continued growth for GLP-1 receptor
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Second, GLP-1s act on brain receptors that regulate hunger and satiety

In this capacity ADA functions as a costimulatory signal that potentiates T cell activation and induces the production of the T-helper cell (Th1) pro-inflammatory cytokines

Diabetes 62: 2595-2604, 2013

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Rodent studies showed thyroid C-cell tumours at high doses, but human trials have not demonstrated increased thyroid cancer incidence over follow-up periods of 25 years
