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Population-Specific Research Needs Geriatric considerations: The prescription of SSRIs in older adults presents unique clinical challenges that extend beyond simple dose adjustment, encompassing age-related pharmacokinetic alterations, extensive polypharmacy, and multiple medical comorbidities that collectively increase vulnerability to adverse effects such as hyponatremia, falls, and clinically significant drug-drug interactions

Preserving brain structure and function , as suggested by trials like ELAD: less loss of brain volume, possibly less cognitive decline, at least in early/mild disease

51,54,56,59,60 Interestingly, one study with liraglutide concluded that in addition to being a woman, a higher baseline BMI was associated with greater body mass reduction

Insulin is a peptide hormone that is produced and released by islets pancreatic cells, that finely regulates the glucose uptake from blood into liver, fat, and skeletal muscle cells