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I will classify these agents as GLP-1-based therapies in the understanding that these compounds or combinations may have actions on other receptors as well

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Preclinical in vivo evidence: energy expenditure, substrate selection, and adiposity In chow-fed mice kept at thermoneutrality, repeated SLU-PP-332 administration increases energy expenditure, lowers RER (favoring fat over carbohydrate oxidation), and reduces adipocyte size, without changing food intake or spontaneous locomotor activity

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