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Nevertheless, the currently available evidence remains indirect and is insufficient to directly demonstrate either a synergistic antitumor effect of GLP-1/GCG co-agonism or an antitumor effect mediated through GCGR activation alone

The reason for this is because there are limited studies on the pathophysiology in children and animal models that fully recapitulate pediatric MASLD/MASH

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doi: 10.1210/jc.2017-00469

Consistent with this expectation, Argyrakopoulou et al reported that in a cohort of obese individuals treated with liraglutide, the dominant change was a reduction in fat mass, accompanied by only a minimal decline in lean mass