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After treatment, serotonin reuptake transporter (SERT) increased, while tryptophan hydroxylase-1 (TPH-1) decreased in the colon, showing that exendin-4 may reduce pain by regulating SERT and TPH-1 levels

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GLP-1 receptors are distributed throughout the gastrointestinal tract

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Physicians assess whether patients can realistically maintain the necessary level of protocol compliance before prescribing oral formulations

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References [1] S

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Nutr Metab (Lond) 8:68 Cava E, Yeat NC, Mittendorfer B (2017) Preserving healthy muscle during weight loss

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