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This matters because the therapeutic effect, appetite suppression, reduced caloric intake, and weight loss, comes from the semaglutide

Wegovy has a half-life of around seven days

Medications that act on GLP-1 receptors, such as Ozempic and Wegovy, can negatively impact muscle mass, bone density and resting metabolism

So far, no significant hypoglycaemia signal has been seen, likely because GLP-1 and GIP agonism counterbalance glucagons glucose-raising effect, but this remains an area of ongoing surveillance

If you do not have metabolic disease, the idea of using GLP-1 purely for dementia prevention is more speculative